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Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

 E-Book
Sofort lieferbar | Lieferzeit:3-5 Tage I
ISBN-13:
9781118644584
Einband:
E-Book
Seiten:
576
Autor:
Atul Tiwari
eBook Typ:
PDF
eBook Format:
E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:

This groundbreaking, multidisciplinary work is one of the first books to cover Nanotheragnostics, the new developmental edge of nanomedicine. Through a collection of authoritative chapters, the book reports on nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities. An invaluable reference for researchers in materials science, bioengineering, pharmacy, biotechnology, and nanotechnology, this volume features four main parts on biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and nanoscaffolds technology.
InhaltsangabePreface xv

Part I: Biomedical nanomaterials

1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1
Thomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette

1.1 Introduction 2

1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5

1.2.1 Generalities on Emulsions 5

1.2.2 Nanoemulsion vs. Microemulsion, a Thermodynamic Definition 6

1.3 Stable Nanoemulsion Formulation 9

1.3.1 Nanoemulsion Production 9

1.3.2 Nanoemulsion Stability Rules 11

1.3.3 Nanoemulsion Formulation Domain 16

1.3.4 Conclusion on the Formulation of Stable Nanoemulsions 21

1.4 Nanoencapsulation in Lipid Nanoparticles 21

1.4.1 Aim ofActive Encapsulation 21

1.4.2 Lipid Complexity and Influence of Their Physical State 23

1.4.3 Amorphous Lipids for a Large Range of Encapsulated Molecules 27

1.4.4 Lipids Viscosity and Release 31

1.4.5 Conclusion on the Use ofAmorphous Lipid Matrices for Control OverActive Encapsulation and Release 34

1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35

1.5.1 Nanoemulsion Biocompatibility 35

1.5.2 Classical TargetingApproach by Chemical Grafting – Example of Tumor Cell Targeting by Crgd Peptide for Cancer Diagnosis and Therapy 38

1.5.3 New ‘No Synthesis Chemistry’Approach – Example of Pal-KTTKS andAsiaticoside Targeting for CosmeticActives Delivery 41

1.5.4 Conclusion on Nanoemulsions Application in Biosciences 46

1.6 General Conclusion 47

References 48

2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57
Angel Contreras-García and Emilio Bucio

2.1 Introduction 58

2.2 Polymeric-based Core-shell Colloid 61

2.3 Proteins and Peptides 64

2.4 Drug Conjugates and Complexes with Synthetic Polymers 65

2.5 Dendrimers, Vesicles, and Micelles 67

2.5.1 Dendrimers 67

2.5.2 Vesicles 68

2.5.3 Micelles 70

2.6 Smart Nanopolymers 71

2.6.1 Temperature and pH Stimuli-responsive Nanopolymers 72

2.6.2 Hydrogels 72

2.6.3 Stimuli Responsive Biomaterials 73

2.6.4 Interpenetrating Polymer Networks 74

2.7 Stimuli Responsive Polymer-metal Nanocomposites  75

2.8 Enzyme-responsive Nanoparticles 78

Acknowledgements 83

References 83

3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97
R. Sharma and S. Kwon

3.1 Introd MWCNT Carbon Nanotubes 116

3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120

3.6.1 An In Vivo Model CNT-Induced Inflammatory Response in Alveolar Co-culture System 122

3.6.2 Static Model: 3-Dimensional Tissue Engineered Lung 124

3.6.3 Dynamic Model: Integration of 3D Engineered Tissues into Cyclic Mechanical Strain Device 126

3.6.4 In Vivo MR Microimaging Technique of Rat Skin Exposed to CNT 127

3.7 New Lessons on CNT Nanocomposites 130

3.8 Conclusions 135

Part II: Advanced nanomedicine

4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149
Bruno Therrien

4.1 Introduction 149

4.2 Complex-in-a-Complex Systems 150

4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155

4.4 Exploiting the Enhanced Permeability and Retention Effect 159

4.5 Incorporation of Photosensitizers in Metalla-assemblies 162

4.6 Conclusion 165

Acknowledgments 165

References 166

5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169
Jyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen

5.1 Lung Structure and Physiology 170

5.2 Common Lung DiseasesAnd Treatment Methods 171

5.2.1 Lung Cancer 171

5.2.2 PulmonaryArterial Hypertension 172

5.2.3 Obstructive Lung Diseases 173

5.3 Types of Nanoparticles (NPs) 173

5.3.1 Liposomes 174

5.3.2 Micelles 176

5.3.3 Dendrimers 177

5.3.4 Polymeric Micro/Nanoparticles 177

5.4 Methods for Pulmonary Delivery 179

5.4.1 Nebulization 179

5.4.2 Metered Dose Inhalation (MDI) 182

5.4.3 Dry Powder Inhalation (DPI) 183

5.4.4 IntratrachealAdministration 183

5.5 Targeting Mechanisms 184

5.5.1 Passive Targeting 184

5.5.2 Active Targeting 185

5.5.3 Cellular Uptake Mechanisms 188

5.6 TherapeuticAgents Used for Delivery 188

5.6.1 ChemotherapeuticAgents 188

5.6.2 Bioactive Molecules 190

5.6.3 Combinational Therapy 190

5.7 Applications 191

5.7.1 Imaging/DiagnosticApplications 191

5.7.2 TherapeuticApplications 193

5.7.3 Lung Remodeling and Regeneration 194

5.8 Design Considerations of NPs 195

5.8.1 Half-life of NPs 195

5.8.2 Drug Release Mechanisms 195

5.8.3 Clearance Mechanisms in the Lung 196

5.9 Current Challenges and Future Outlook 197

6 Nano-Sized Calcium Phosphate (CaP) Carrier calcium Phosphates: Future Trends of the CaPDelivery Systems 221

Acknowledgements 223

References 223

7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233
Jingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen

7.1 Introduction 233

7.2 Controlled Drug Delivery Systems Based on Organics Modified

7.2.1 MSNs-based Drug Delivery Systems Controlled by Physical Stimuli 238

7.2.2 MSNs-based Drug Delivery Systems Controlled by Chemical Stimuli 246

7.3 Conclusions 258

References 259

Part III: Nanotheragnostics

8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263
Weitai Wu and Shuiqin Zhou

8.1 Introduction 264

8.2 Mechanisms of Response 268

8.2.1 Reception of an External Signal 268

8.2.2 Volume Phase Transition of the Hybrid Nanogels 275

8.2.4 Regulated Drug Delivery 282

8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285

8.3.1 Synthesis of the Hybrid Nanogels from Pre-synthesized Polymer Nanogels 285

8.3.2 Synthesis of the Hybrid Nanogels from Pre-synthesized Inorganic NPs 289

8.3.3 Synthesis of the Hybrid Nanogels by a Heterogeneous Polymerization Method 292

8.4 Applications 293

8.4.1 Responsive Polymer-inorganic Hybrid Nanogels in Optical Sensing 293

8.4.2 Responsive Polymer-inorganic Hybrid Nanogels in Diagnostic Imaging 299

8.4.3 Responsive Polymer-inorganic Hybrid Nanogels in Drug Delivery 301

References 306

9 Core/Shell Nanoparticles for Drug Delivery and Diagnosis 315
Hwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk

9.2 Core/Shell NPs from Polymeric Micelles 319

9.2.1 Polymeric Micelles with Physical Drug Entrapment 319

9.2.2 Polymeric Micelles with Drug Conjugation 321

9.2.3 Polymeric Micelles Formed by Temperature-Induced Phase Transition 323

9.3 Phospholipid-based Core/Shell Nanoparticles 325

9.4 Layer-by-Layer-Assembled Core/Shell Nanoparticles 329

9.5 Core/Shell NPs for Diagnosis 330

9.4 Conclusions 331

Ackn

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