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Management of Breast Diseases

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Ismail Jatoi
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This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, and medical oncologists will find this book useful. The management of breast diseases requires a multidisciplinary approach, and this textbook therefore includes the views of a wide range of specialists from throughout the world. Today the treatment of breast diseases is largely predicated on the results of randomized prospective trials. The results of many clinical trials are discussed in detail, and readers will find this book to be a useful guide to the evidence-based treatment of breast diseases.The revised edition provides a comprehensive update of the previous version of the book. Specifically, it contains 2 new chapters: “Molecular Classification of Breast Cancer” and “Breast Cancer Molecular Testing for Prognosis and Prediction”. In addition, since publication of the previous edition, the results of numerous adjuvant systemic therapy and neo-adjuvant systemic therapy trials have been published, and this edition provides a comprehensive overview of these trials and discusses how they have changed the management of breast cancer. Similarly, there have been, in the last few years, important new developments in the local therapy of breast cancer. This edition discusses these new developments and particularly recent developments and controversies concerning the management of the axilla in patients with primary breast cancer. New guidelines with respect to radiotherapy are also reviewed and discussed. Finally, all chapters in the book are thoroughly revised and updated to provide readers with current understanding of the biology and treatment of breast cancer.
1. Anatomy and Physiology of the Breast
Martha C. Johnson and Mary L. Cutler

2. Congenital and Developmental Abnormalities of the Breast

Kristin Baumann and Telja Pursche

3. Nipple Discharge

Jill R. Dietz

4. Mastalgia

Amit Goyal and Robert E. Mansel

5. Management of Common Lactation and Breastfeeding Problems

Lisa H. Amir and Verity H. Livingstone

6. Evaluation of a Breast Mass

Alastair M. Thompson and Andrew Evans 7. Breast Cancer Epidemiology

Alicia Brunßen, Joachim Hübner, Alexander Katalinic, Maria R. Noftz and Annika Waldmann

8. Breast Cancer Screening

Ismail Jatoi

9. Breast Imaging

Anne C. Hoyt and Irene S. Tsai

10. Premalignant and Malignant Breast Pathology

Hans-Peter Sinn

11. Breast Cancer Molecular Testing for Prognosis and Prediction

Nadia Harbeck

12. Molecular Classification of Breast Cancer

Maria Vidal, Laia Paré and Aleix Prat

13. Ductal Carcinoma in Situ

Ian H. Kunkler

14. Surgical Considerations in the Management of Primary Invasive Breast Cancer

Carissia Calvo and Ismail Jatoi

15. Management of the Axilla

John R. Benson and Vassilis Pitsinis

16. Breast Reconstructive Surgery

Yash J. Avashia, Amir Tahernia, Detlev Erdmann and Michael R. Zenn

17. The Role of Radiotherapy in Breast Cancer Management

Mutlay Sayan and Ruth Heimann

18. Adjuvant Systemic Treatment for Breast Cancer: An Overview

Rachel Nirsimloo and David A. Cameron

19. Endocrine Therapy

Olivia Pagani and Rosaria Condorelli

20. Systemic Therapy

Frederik Marmé

21. HER2-Targeted Therapy

Phuong Dinh and Martine J. Piccart

22. Inflammatory and Locally Advanced Breast Cancer

Tamer M. Fouad, Gabriel N. Hortobagyi and Naoto T. Ueno

23. Neoadjuvant Systemic Treatment (NST)

Cornelia Liedtke and Achim Rody 24. Metastatic Breast Cancer

Berta Sousa, Joana M. Ribeiro, Domen Ribnikar and Fátima Cardoso

25. Estrogen and Breast Cancer in Postmenopausal Women: A Critical Review

Joseph Ragaz and Shayan Shakeraneh

26. Estrogen and Cardiac Events with All-Cause Mortality: A Critical Review

Joseph Ragaz and Shayan Shakeraneh

27. Breast Diseases in Males

Darryl Schuitevoerder and John T. Vetto

28. Breast Cancer in the Older Adult

Emily J. Guerard, Madhuri V. Vithala and Hyman B. Muss 29. Breast Cancer in Younger Women

Manuela Rabaglio and Monica Castiglione

30. Psychological Support for the Breast Cancer Patient

Donna B. Greenberg

31. Management of the Patient with a Genetic Predisposition for Breast Cancer

Sarah Colonna and Amanda Gammon

32. Chemoprevention of Breast Cancer

Jack Cuzick

33. Design, Implementation, and Interpretation of Clinical Trials

Carol K. Redmond and Jong-Hyeon Jeong

34. Structure of Breast Centers

David P. Winchester

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